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Tumor volume in subcutaneous mouse xenografts measured by microCT is more accurate and reproducible than determined by 18F-FDG-microPET or external caliper. Mette Munk Jensen,; Jesper Tranekj?r Jorgensen,; Tina Binderup and; Andreas Kj?rEmail author. BMC Medical Imaging20088:16.
Recently, the RECIST (Response Evaluation Criteria in Solid Tumors) was proposed as a new guideline for evaluating the response using unidimensional measurements instead of bidimensional measurements, a lower number of measured lesions, the withdrawal of the progression criteria based on the isolated increase
criteria. 2. Purpose of this guideline. This guideline describes a standard approach to solid tumour measurement and definitions for objective assessment of change in tumour size for use in adult and paediatric cancer clinical trials. It is expected these criteria will be useful in all trials where objective response is the primary
Optimally, one observer should perform all tumor measurements in a given study in order to minimize variables. Calipers must be used to measure tumor size in order to avoid discrepancies. Tumor size limits (exceptions must be justified in the AUP). Single tumor: must not exceed 15mm (1.5 cm) at the largest diameter in an
The problem is that by doing so you can not adress properly the issue of infiltrating inflammatory tissue, necrosis, calcified parts of the tumors that may overestimate the actual size of the tumor. Functional imaging is probably a good option to measure accurately a tumor volume - but it's quite costly as compared with a caliper
criteria proposed by the revised Response Evaluation Criteria in Solid Tumors (RECIST) guideline (version 1.1) [Eur J Ca 45:228-247, 2009]. Changes in the largest diameter. (unidimensional measurement) of the tumor lesions and the shortest diameter in the case of malignant lymph nodes are used in the RECIST criteria.
1 Oct 2003 Recently, the Response Evaluation Criteria in Solid Tumors Group (RECIST) proposed new guidelines using unidimensional measurement. Theoretically, the simple sum of the maximum diameters of individual tumors is more linearly related to cell kill than is the sum of the bidimensional products.
When the primary endpoint of the study is objective response evaluation, ultrasound (US) should not be used to measure tumor lesions. It is, however, a possible alternative to clinical measurements of superficial palpable lymph nodes, subcutaneous lesions and thyroid nodules. US might also be useful to confirm the
The pivotal role of imaging in response assessment is recognized, and specific imaging guidelines are defined. However These criteria (WHO criteria) were based on bi- or two-dimensional (2D) measurements because it was not possible to measure tumor volume with the imaging technology available at that time (Fig 1).
PURPOSE: To evaluate the variability in bidimensional computed tomography (CT) measurements obtained of actual tumors and of tumor phantoms by use of three measurement techniques: hand-held calipers on film, electronic calipers on a workstation, and an autocontour technique on a workstation. MATERIALS AND